HRI stress signaling and HbF production

Metal-Induced Oxidative Stress and Cellular Signaling Alteration in Animals

Contamination by heavy metals has attracted increasing attention considering the ability of these elements in producing serious consequence to ecosystem, and especially on animals health. Due to their widespread use in human activities such as industry, agriculture and even as medicine (e.g. arsenic, selenium and platinum), numerous health risks may be associated with exposure to these substanc...

HRI and bacterial infection

Phosphorylation of eIF2α by its kinases is a stress response universally conserved among the eukaryota. Previously, we reported that the eIF2α kinases Heme Regulator Inhibitor (HRI) and Protein Kinase R (PKR) control distinct activities of diverse bacterial pathogens. Specifically for Listeria monocytogenes, it was shown that in HRIdeficient cells there was a reduction in the translocation of t...

DELIVERABLE D2.2.2 Conceptual HRI Design, Usability Testing, HRI Interaction Patterns, and HRI Principles for Remotely Controlled Service Robots (Final)

HbF and HbA production in erythroid cultures from human fetuses and neonates.

The synthesis of ‘yand /9-globin chains was investigated in erythroid cultures from first and second trimester fetuses as well as neonates in order to examine whether the differences in production of HbA and F in the fetal and newborn ontogenetic stages reflect in vivo predetermined differences in commitment among erythroid progenitors. Cultures of erythroid progenitors from first and second tr...

Stress Signaling II: Calcium Sensing and Signaling

Calcium is an essential second messenger in plant signaling networks. Many environmental and developmental stimuli induce an increase in cytosolic calcium to trigger different physiological responses. The specificity of Ca2+ signaling is achieved by a combination of distinct calcium signatures that are generated by specific calcium channels, pumps and transporters, and diverse calcium sensors t...